To obtain a substituted quinoline derivative used as a medicament useful as an antiviral agent, especially a therapeutic agent for AIDS.
This compound is represented by formula II [(n) is 0-4; R1 is a halogen, CF3, OH, an alkyl, an alkoxy, an alkylthio, NO2, NH2, CN, phenyl, phenoxy or the like; X is O, S, Se, NR2 or N-O-R2; R2 is H, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an alkylcarbonyl, an aryl, an arylcarbonyl or the like; R5 and R6 are each H, carboxyl, an alkyl, an alkenyl, a cycloalkyl, an alkylcarbonyl, an aryl, a heteroaryl or the like; R3 and R4 are each H, an alkyl, an alkenyl, a cycloalkyl, a cycloalkenyl, an aryl, an arylalkyl, a heteroaryl or the like], e.g. E-4-n-butylene-6-chloro-3,4-dihydro-3,3-dimethylquinolin-2(1H)-one.
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