Title:
置換2-イミダゾール又はイミダゾリン誘導体の使用
Document Type and Number:
Japanese Patent JP2009524617
Kind Code:
A
Abstract:
The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.
Inventors:
Flounder, Gweed
Grapeke, Tubinden Katrin
Henner, Marius
Korzewski, Sabine
Norcross, Roger
Henry Starder
Grapeke, Tubinden Katrin
Henner, Marius
Korzewski, Sabine
Norcross, Roger
Henry Starder
Application Number:
JP2008551760A
Publication Date:
July 02, 2009
Filing Date:
January 17, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D233/06; A61K31/4174; A61K31/4178; A61K31/4439; A61P1/14; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/36; C07D233/20; C07D233/22; C07D233/24; C07D233/56; C07D233/64; C07D401/06; C07D403/06; C07D405/06; C07D409/06
Domestic Patent References:
| JP2002522359A | 2002-07-23 | |||
| JP2001302643A | 2001-10-31 | |||
| JP2001526286A | 2001-12-18 | |||
| JPS62145067A | 1987-06-29 | |||
| JPS59193875A | 1984-11-02 | |||
| JPS52105131A | 1977-09-03 | |||
| JPS4938273B1 | 1974-10-16 |
Foreign References:
| WO2002022801A2 | 2002-03-21 | |||
| WO1998012183A1 | 1998-03-26 | |||
| US6124338A | 2000-09-26 |
Other References:
JPN6012067624; Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｒｅｓｅａｒｃｈ ｖｏｌ．１０， ｎｏ．５, 2001, ｐ．３０９-３１７
JPN6012067625; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ｖｏｌ．１４， ｎｏ．１８, 2004, ｐ．４６９７-４６９９
JPN6012067625; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ｖｏｌ．１４， ｎｏ．１８, 2004, ｐ．４６９７-４６９９
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito