Title:
スルホンアミド誘導体またはその薬学的に許容される酸付加塩
Document Type and Number:
Japanese Patent JP6775803
Kind Code:
B2
Abstract:
The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I):
wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
Inventors:
Hiroshi Nagase
Masashi Yanagisawa
Takeshi Saito
Nozomi Kusumura
Yoko Irukayama
Masashi Yanagisawa
Takeshi Saito
Nozomi Kusumura
Yoko Irukayama
Application Number:
JP2017523722A
Publication Date:
October 28, 2020
Filing Date:
June 10, 2016
Export Citation:
Assignee:
University of Tsukuba
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07C311/37; A61K31/18; A61K31/196; A61K31/245; A61K31/27; A61K31/341; A61K31/36; A61K31/381; A61K31/4164; A61K31/4166; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/513; A61K31/551; A61P3/04; A61P3/10; A61P25/24; A61P25/26; A61P31/04; A61P43/00; C07C317/28; C07C335/20; C07D213/40; C07D213/75; C07D213/76; C07D213/81; C07D233/02; C07D233/36; C07D239/10; C07D243/04; C07D307/54; C07D317/66; C07D317/68; C07D333/36; C07D417/04
Domestic Patent References:
| JP2008517930A | ||||
| JP2009533419A | ||||
| JP2011510037A | ||||
| JP2009503106A | ||||
| JP2000319249A | ||||
| JP2007536348A | ||||
| JP2006519785A | ||||
| JP2005534684A |
Foreign References:
| WO2015088000A1 | ||||
| WO2014006402A1 | ||||
| US6153585 | ||||
| WO2016133160A1 |
Other References:
STN International,file REGISTRY [online],[令和2年4月28日検索],CAS Registry No. 423726-65-2(Entered STN: 31 May 2002), 350246-87-6(Entered STN: 03 Aug 2001)
NAGAHARA T. et al.,Design and synthesis of non-peptide, selective orexin receptor 2 agonists,J. MED. CHEM.,2015年,vol.58 no.20,pp.7931-7937, Publication date(Web): August 12, 2015
NAGAHARA T. et al.,Design and synthesis of non-peptide, selective orexin receptor 2 agonists,J. MED. CHEM.,2015年,vol.58 no.20,pp.7931-7937, Publication date(Web): August 12, 2015
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki