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Title:
スルホンアミド置換クロマン、その製法、医薬または診断薬としてのその使用およびそれを含有する医薬製剤
Document Type and Number:
Japanese Patent JP4279920
Kind Code:
B2
Abstract:
Sulfonamide-substituted chromane derivatives (I) are new. Sulfonamide-substituted chromane derivatives of formula (I), and salts of (I), are new: R<1>, R<2> = H, CF3, C2F5, C3F7, 1-6C alkyl, or optionally substituted phenyl; or R<1> +R<2> = a 2-10C alkylene chain; R<3> = R<10>-VCnH2n-NR<11> or R<10>-CnH2n; V = CnH2n in which one CH2 group may be replaced by O, CO, S, SO, SO2 or N(R<12>a); R<10> = H, Me, Cy, CF3, C2F5 or C3F7; R<11> = H or; or R1<0> + R<11> = a bond, provided that n is not less than 3; n = 0-10; R<4> = R<13>-CrH2r-Z-CqH2q; q, r = 0-8; Z = eg. CO-NH<14> or OCO-NR<14>; R<14> = eg. H or 1-3C alkyl; R<5>, R<6>, R<7>, R<8> = H, F, Cl, Br, I, 1-5C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, Y-CsH2s-R<18> or optionally substituted phenyl; Y = eg. O, CO, CO-O, O-CO, S, SO or SO2; s = 0-6; R<18> = eg. H, CF3C2F5, C3F7, COOH, 1-piperidyl, 1-pyrrolidinyl, 4-morpholinyl, pyridyl, thienyl, imidazolyl, quinolyl, isoquinolyl or phenyl; R<9> = eg. H, OH, 1-3C alkoxy; B' = H; or R<9> + B' = a bond

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Inventors:
Joachim Brendel
Uwe Gerlach
Hans Yotzhen Lang
Klaus Vuitman
Application Number:
JP27216798A
Publication Date:
June 17, 2009
Filing Date:
September 25, 1998
Export Citation:
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Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/35; C07D311/68; A61K31/352; A61K31/353; A61K31/44; A61K31/443; A61K31/4433; A61K31/445; A61K31/495; A61P1/00; A61P1/12; A61P9/00; A61P9/04; A61P9/06; A61P43/00; C07D311/70; C07D311/72; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D521/00
Domestic Patent References:
JP1151570A
JP2300182A
Other References:
SOLL, R.M., et al.,Bioorg. Med. Chem. Lett.,4(5),pp.769-773 (1994)
LOHEMANN, E., et al.,Pfluegers Arch.- Eur. J. Physiol.,429,pp.517-530 (1995)
SUESSBRICH, H., et al.,FEBS Lett.,396,pp.271-275 (1996)
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura



 
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