To obtain a new compound useful as a matrix metalloprotease inhibitor.
This compound is represented by formula I [R1 is H or a 1-4C alkyl; R2 is H, a 1-8C alkyl, phenyl, etc.; J is a single bond, a 2-4C alkylene, a group of formula II (R4 and R5 are each H, a 1-4C alkyl, etc.), etc.; G is (CH2)m, etc.; (m) is 2-4; E is CONR3, NR3CO, COO, OCO, etc., (R3 is H, a 1-4C alkyl, etc.); A is H, a 1-8C alkyl or a 3-7C cycloalkyl or Ar; Ar is a carbon ring, a heterocyclic aryl, etc.], e.g. N-[[4-(benzoylamino)phenyl]sulfonyl]glycine. The compound of formula I is obtained by subjecting a compound of formula III (J1 is same as J; R2-1 is a 1-8C alkyl, phenyl, etc.) to amidation reaction with a compound of the formula A1-J1-COOH (A1 is same as A) and as necessary deprotecting the reaction product. The compound is useful for preventing and treating rheumatics, arthrosteitis, osteoporosis, periodontal diseases, interstitial nephritis, arteriosclerosis, liver emphysema, cirrhosis, corneal injury, autoimmune disease, etc.
KANAZAWA HIDEKAZU
SUGIURA TSUNEYUKI
MIYAZAKI TORU
ONO HIROYUKI
