Title:
SUPPRESSOR FOR PRODUCING CYTOKINE AND SUPPRESSOR FOR ADHESION
Document Type and Number:
Japanese Patent JPH10152437
Kind Code:
A
Abstract:
To obtain the subject medicine enabling suppression of production of cytokine and suppression of adhesion by including a specific thiazole derivative.
This medicine comprises a compound represented by formula I [R1 is an (alkoxy-substituted) phenyl group; R2 is a group of formula II (R3 is carboxyl, a lower alkoxy, etc.; (m) is 1-3)], especially preferably 6-[2-(3,4- diethoxyphenyl) thiazol-4-yl]pyridine-2-carboxylic acid as an acid as an active ingredient. The medicine is effective against various kinds of diseases accompanied by abnormality of production of cytokine e.g. TNF-α, IL-1B, IL-6 or IFN-γ and can be used as an agent for especially preventing and treating chronic rheumatoid arthritis, endotoxin shock, etc.
Inventors:
CHIHIRO MASATOSHI
MATSUZAKI NORIYUKI
NAGAMOTO TAKASHI
TSUDA GORO
SUEYOSHI SHINOBU
MORI TOYOKI
KITANO KAZUYOSHI
TAKEMURA ISAO
YAMASHITA HIROSHI
KURIMURA MUNEAKI
TAFUSA FUJIO
MATSUZAKI NORIYUKI
NAGAMOTO TAKASHI
TSUDA GORO
SUEYOSHI SHINOBU
MORI TOYOKI
KITANO KAZUYOSHI
TAKEMURA ISAO
YAMASHITA HIROSHI
KURIMURA MUNEAKI
TAFUSA FUJIO
Application Number:
JP26569497A
Publication Date:
June 09, 1998
Filing Date:
September 30, 1997
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD
International Classes:
C07D277/22; A61K31/425; A61K31/426; A61K31/44; A61K31/505; A61P1/00; A61P1/16; A61P3/08; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P17/00; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D277/20; C07D277/24; C07D277/28; C07D277/30; C07D417/04; (IPC1-7): A61K31/425; A61K31/425; A61K31/44; A61K31/505; C07D277/22; C07D277/24; C07D277/28; C07D277/30; C07D417/04
Domestic Patent References:
| JPH0665222A | 1994-03-08 | |||
| JPH0551318A | 1993-03-02 | |||
| JPH06192122A | 1994-07-12 | |||
| JPH0892250A | 1996-04-09 | |||
| JPH08131178A | 1996-05-28 |
Attorney, Agent or Firm:
Eiji Saegusa (10 others)