SYNTHESIS OF A-RING SYNTHON OF 19-NOR-1-ALFA, 25- DIHYDROXYVITAMIN D3 FROM (D)-GLUCOSE

Title:

SYNTHESIS OF A-RING SYNTHON OF 19-NOR-1-ALFA, 25- DIHYDROXYVITAMIN D3 FROM (D)-GLUCOSE

Document Type and Number:

Japanese Patent JP2003176250

Kind Code:

A

Abstract:

To provide a method of synthesizing phosphine oxide being a synthon for ring A used for preparing 19-nor-vitamin D compound and provide a new synthetic intermediate that is formed on the way of the synthetic route.

In this new synthetic process, the phosphine oxide is prepared from (D)-glucose.

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Inventors:

DELUCA HECTOR F
SHIMIZU MASATO
YAMADA SACHIKO

Application Number:

JP2002220721A

Publication Date:

June 24, 2003

Filing Date:

July 30, 2002

Export Citation:

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Assignee:

WISCONSIN ALUMNI RES FOUND

International Classes:

C07C43/196; C07C45/29; C07C45/60; C07C49/753; C07F7/18; C07F9/53; C07H3/02; C07H9/04; (IPC1-7): C07C43/196; C07C49/753; C07F7/18; C07F9/53

Other References:

JPN6009046245, Ｎｏｒｉａｋｉ　ＩＷＡＳＥ　ｅｔ　ａｌ．, "Ｓｕｂｓｔｒａｔｅ　Ｓｐｅｃｉｆｉｃｉｔｙ　ｏｆ　２−Ｄｅｏｘｙ−ｓｃｙｌｌｏ−ｉｎｏｓｏｓｅ　Ｓｙｎｔｈａｓｅ，　ｔｈｅ　Ｓｔａｒｔｅｒ　Ｅｎｚｙｍｅ　ｆｏｒ　２−Ｄｅｏｘｙｓｔｒｅｐｔａｍｉｎｅ", Ｂｉｏｓｃｉ．　Ｂｉｏｔｅｃｈｎｏｌ．　Ｂｉｏｃｈｅｍ．, 1998, Ｖｏｌ．６２，　Ｎｏ．１２, ｐ．２３９６−２４０７

Attorney, Agent or Firm:

Kazuo Shamoto (5 outside)

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