Title:
癌胎児抗原をコードする合成遺伝子およびその使用
Document Type and Number:
Japanese Patent JP2007523610
Kind Code:
A
Abstract:
Synthetic polynucleotides encoding human carcinoembryonic antigen (CEA) are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimed human CEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
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Inventors:
La Monica, Nikola
Ram, Armin
Carmena, Menuni
Sabino, Rotsuko
Ram, Armin
Carmena, Menuni
Sabino, Rotsuko
Application Number:
JP2006505382A
Publication Date:
August 23, 2007
Filing Date:
May 03, 2004
Export Citation:
Assignee:
ESTACH YOUT DAY LICHIERQUE DAY VIOLOSIA MORE CORRALE PI ANGE ELETS ESET PEAR
International Classes:
C12N15/09; A61K39/00; A61P35/00; C07K14/47; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/85; C12N15/861
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura