To provide: a drilling system including a motor that produces a sonic, linear oscillatory motion for extracting a frozen biological sample from a stored frozen specimen; and methods of use thereof for extracting without thawing the remainder of the specimen.
An apparatus comprises: a drill that is brought into contact with a specimen within a container, where the drill comprises a motor that actuates a hollow bit coring needle 33; and a grip that holds the specimen and has an open end of the container proximal to the needle. The motor impels the needle into the specimen within the container, and the frozen sample is removed from the specimen in absence of thawing of the specimen within the container. A stator and slider component 32 is operated by a servo controller which can communicate and be programmed through a port of a computer equipped with software.
JEFFREY RUBERTI
JOHN SLUSARZ
NICHOLAS GOULAS
ERIN RUSH
TREVOR EHRET
UNIV NORTHEASTERN
| JP2004500891A | 2004-01-15 | |||
| JPH09508789A | 1997-09-09 |
| US20030054342A1 | 2003-03-20 | |||
| US8448456B2 | 2013-05-28 | |||
| CN1391094B |
JPN7014002669; Ｍａｒｌｅｎａ Ｓｃｈｏｅｎｂｅｒｇ Ｆｅｊｚｏ ａｎｄ Ｄｅｎｎｉｓ Ｊ． Ｓｌａｍｏｎ: 'Ｆｒｏｚｅｎ Ｔｕｍｏｒ Ｔｉｓｓｕｅ Ｍｉｃｒｏａｒｒａｙ Ｔｅｃｈｎｏｌｏｇｙ ｆｏｒ Ａｎａｌｙｓｉｓ ｏｆ Ｔｕｍｏｒ ＲＮＡ， ＤＮＡ， ａｎｄ Ｐｒｏｔｅｉｎｓ' Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐａｔｈｏｌｏｇｙ Ｖｏｌ． １５９， Ｎｏ．５, 200111, ｐｐ． １６４５-１６５０
JPN7014002670; Ｋｉｒｓｔｅｎ Ｓｔｒｕｃｋｍａｎｎ ｅｔ ａｌ．: 'Ｉｍｐａｉｒｅｄ Ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｔｈｅ Ｃｅｌｌ Ｃｙｃｌｅ Ｒｅｇｕｌａｔｏｒ ＢＴＧ２ Ｉｓ Ｃｏｍｍｏｎ ｉｎ Ｃｌｅａｒ Ｃｅｌｌ Ｒｅｎａｌ Ｃｅｌｌ Ｃａｒｃｉｎｏｍａ' Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ． ６４, 20040301, ｐｐ． １６３２-１６３８
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto