Ｔ細胞レセプター - Immunocoa Limited

Title:

Ｔ細胞レセプター

Document Type and Number:

Japanese Patent JP7254519

Kind Code:

B2

Abstract:

The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the germline cancer antigen MAGE A4. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGE A4 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease

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Inventors:

Haze, connor
Hibbert, Linda
Ridi, Nathaniel
Mahon cod
Raman, Marine

Application Number:

JP2018552859A

Publication Date:

April 10, 2023

Filing Date:

April 07, 2017

Export Citation:

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Assignee:

Immunocoa Limited

International Classes:

C12N15/12; A61K35/12; A61K38/17; A61K39/395; A61K48/00; A61P35/00; A61P37/04; C07K14/725; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12N15/63; C12P21/02

Domestic Patent References:

JP2013126415A

Foreign References:

WO2014118236A2
WO2000020445A2

Other References:

Eur. J. Immunol.,1999年,Vol.29, No.10,pp.3329-3337

Attorney, Agent or Firm:

Nobuhisa Nogawa
Hiroshi Sumikawa
Shintaro Nogawa
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita

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