Title:
テトラサイクリンの塩
Document Type and Number:
Japanese Patent JP6883578
Kind Code:
B2
Abstract:
A tetracycline salt comprising a tetracycline and an organic acid wherein the organic acid is oxalic acid or maleic acid is provided. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate, or lymecycline oxalate. A pharmaceutical formulation comprising a tetracycline salt according to the invention is also provided, as is a medical device having coated thereon a salt or pharmaceutical formulation according to the invention. A salt of the invention, or a formulation of the invention are also provided for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection. There is also provided a method of preparing a tetracycline salt, which method comprises reacting a tetracycline base with an excess of an organic acid in a solvent.
Inventors:
Sobral, Lewis
Santana de Arruda, Revere
Figueiredo, Margarida
Raven, Antonios
Philippe, Ana Paula
Santana de Arruda, Revere
Figueiredo, Margarida
Raven, Antonios
Philippe, Ana Paula
Application Number:
JP2018526664A
Publication Date:
June 09, 2021
Filing Date:
November 24, 2016
Export Citation:
Assignee:
Hobione Scientia Limited
International Classes:
C07C237/26; A61K31/65; A61L27/28; A61L27/54; A61L29/08; A61L29/16; A61L31/08; A61L31/16; A61P27/02; A61P29/00; A61P31/00; C07C51/41; C07C55/06; C07C57/145; C07C231/12
Domestic Patent References:
| JP2012520745A | ||||
| JP2003523925A |
Foreign References:
| US3036120 | ||||
| CN1843505A | ||||
| BE615425A | ||||
| US20090099376 | ||||
| FR892088B1 | ||||
| US2929837 | ||||
| DE1045398A |
Other References:
Bulletin of the Agricultural Chemical Society of Japan,1960年,24,p.657-666
Agr. Biol. Chem.,1961年,25(4),p.333-339
Agr. Biol. Chem.,1961年,25(4),p.333-339
Attorney, Agent or Firm:
西浦 ▲嗣▼晴
High Miki Yoshiki
Tadashi Deyama
High Miki Yoshiki
Tadashi Deyama