NEW MATERIAL:A tetronolide expressed by formula I (R1 and R2 are H or acyl; R3 is H, acyl or tetronitrose of formula II) and a salt thereof.
EXAMPLE: 17-O-Tetronitrosyltetronolide expressed by formula III.
USE: An antimicrobial agent, an antitumor agent and a synthetic intermediate therefore, administered intravenously or intraperitoneally in a dose of 0.2W0.5mg/kg/day.
PROCESS: A microorganism, e.g. Micromonospora chalcea XY11091 strain (FERM-P No.4458, NRRL11289), capable of producing a tetronolide compound expressed by formula IV is cultivated in a untrient culture medium, and the compound expressed by formula IV in the compound expressed by formula I in which R1 and R2 are H respectively is obtained from the culture. The hydroxyl group at the 9 or 21 position of the compound expressed by formula IV is acylated by the chemical synthetic method if necessary to give the remaining compound expressed by formula I.
TAMAOKI TATSUYA
SHIRAHATA KIMIKATSU
KASAI MASAJI
HIRAYAMA NARIAKI
MORIMOTO MAKOTO
FUKUI MASANORI
