トリフェニルアルケン誘導体およびエストロゲン選択的受容体モジュレーターとしてのそれらの用途

Japanese Patent JP4202647

B2

The invention provides novel selective estrogen receptor modulator compounds of the general formula:wherein R1 and R2, which are the same or different area) H, halogen, OCH3, OH; orwhere X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, -CH2C=CH or -CH2CH2OH; or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; orc) -Y-(CH2)nCH2-O-R6where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H, -CH2CH2OH, or -CH2CH2Cl; ord) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; andR3 is H, halogen, OH or -OCH3;stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties.

Sederbal, Maruya-Risa
Calapdas, Alya
Cangas, Lauri
Lamin Tausta, Liszt
Herkenen, Pirukko
Benenen, Callervo
Karjaleinen, Alto

JP2001538315A

December 24, 2008

November 01, 2000

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HORMOS MEDICAL LTD.

A61K31/4164; A61K31/085; C07C217/20; A61K31/09; A61K31/10; A61K31/136; A61K31/138; A61K31/145; A61K31/192; A61K31/4453; A61P5/30; A61P5/32; A61P9/02; A61P13/02; A61P15/02; A61P15/12; A61P19/10; A61P25/04; A61P25/20; A61P25/24; A61P25/28; A61P43/00; C07C43/225; C07C43/23; C07C59/68; C07C211/10; C07C211/53; C07C215/16; C07C217/18; C07C323/12; C07C323/25; C07D211/14; C07D233/61; C07D295/092; C07D521/00

JP55100345A
JP58216129A
JP10505079A
JP2002503713A
JP2002517433A

WO1996035417A1

Sota Asahina
Kei Saki
Fumio Akiyama
Hiromu Tanaka

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