PURPOSE: To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability.
CONSTITUTION: A therapeutic agent for hepatosis containing a compound of formula I [X is O or S; Y is thiocarbonyl or methylene; R is H, a halogen, cyano, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylthio, an acyloxy, an acyl, NR1R2 (R1 and R2 are each H, an acyl, an alkyl, an aryl, etc.), dihydropyridyl, CONR3R4 (R3 and R4 are each H, an alkyl, an alkenyl, an aryl, etc.), an alkenyl which may be substituted or an alkoxycarbonyl; (n) is 1 or 2] or its pharmacologically permissible salt, e.g. 1,3-benzoxathiol-2-thione as the active component. Among the compounds of formula I, compounds of formula II [R5 and R6 are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R5 and R6 are not an acyl in the fame time] are new compounds.
MATSUMOTO KAZUO
HIRASE JOJI
OSUGI YUMI
OSHIMA HIROICHI
SOGAWA TAKESHI
MIZUNO YASUO
OKUI YOSHIKAZU
NISHINO MINORU
NISHIGAITO TOSHINORI
