Title:
【発明の名称】1,2-ジアシル化ヒドラジン誘導体および全接着阻害剤としてのそれらの使用
Document Type and Number:
Japanese Patent JPH08512024
Kind Code:
A
Abstract:
The invention concerns acid derivatives of formula I R<1>-CON(R<2>)-N(R<3>)CO-X<1>-Q-X<2>-G I and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, wherein R<1> represents a group of formula II or III in which A is attached meta or para to the position where the group CONR<2>NR<3>CO is attached and is selected from aminomethyl, guanidino and RN=C(NH2)- T is N or CH, and X<3> is a bond, (1-4C)alkylene or, when T is CH, oxy(1-3C)alkylene; R<2> and R<3>, which may be the same or different, represent hydrogen, (1-4C)alkyl or ar(1-4C)alkyl; X<1> is a bond or (1-4C)alkylene; Q is a group of formula IV or V X<2> is a bond, (1-4C)alkylene, oxy(1-3C)alkylene or a group of formula CH2CH(NHXR<4>) in which X is SO2, CO or CO2 and R<4> is (1-6C)alkyl, (6-12C)aryl or (6-12C)aryl(1-4C)alkyl in which the aryl group may optionally be substituted by (1-4C)alkyl; and G is a carboxy group. The invention also concerns processes for the preparation of the acid derivatives of formula I, pharmaceutical compositions containing them and their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.
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Inventors:
Brewster, Andrew George
Colecket, Peter William Rodney
Fall, Alan Wellington
Pierce, robert james
Chatter, Richard Ellen
Colecket, Peter William Rodney
Fall, Alan Wellington
Pierce, robert james
Chatter, Richard Ellen
Application Number:
JP50258395A
Publication Date:
December 17, 1996
Filing Date:
June 23, 1994
Export Citation:
Assignee:
Zeneca Limited
International Classes:
A61K31/195; A61K31/215; A61K31/445; A61K31/4465; A61P7/02; A61P9/08; A61P9/10; A61P25/04; A61P43/00; C07D295/14; C07C243/38; C07C257/18; C07D211/34; C07D211/42; C07D211/46; C07D211/62; C07D295/20; C07D295/215; (IPC1-7): C07C243/38; A61K31/195; A61K31/215; A61K31/445; C07D211/34; C07D211/42; C07D211/46; C07D295/14; C07D295/20
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)