【発明の名称】芳香族アミジン誘導体及びその塩

Japanese Patent JP2879718

B2

An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: wherein the group represented by is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5- or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group. The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.

NAGAHARA TAKAYOSHI
KANETANI NAOAKI
INAMURA KAZUE
YOKOYAMA YUKIO

JP29289292A

April 05, 1999

October 30, 1992

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DAIICHI SEIYAKU KK

A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/235; A61K31/33; A61K31/40; A61K31/4025; A61K31/443; A61K31/4433; A61K31/445; A61K31/4465; A61K31/451; A61K31/495; A61K31/50; A61K31/505; A61P7/02; A61P43/00; C07C255/52; C07C255/54; A61K31/155; C07C255/56; C07C255/58; C07C257/18; C07C323/31; C07C323/32; C07D207/09; C07D207/12; C07D209/04; C07D211/22; C07D211/44; C07D211/46; C07D239/02; C07D239/20; C07D241/02; C07D307/78; C07D307/79; C07D307/80; C07D307/84; C07D333/60; C07D333/68; C07D401/12; C07D403/10; C07D403/12; C07D405/12; C07D409/10; C07D409/12; C07D417/12; C07D521/00; (IPC1-7): C07C257/18; A61K31/155; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/235; A61K31/40; A61K31/445; C07C323/31; C07C323/32; C07D207/12; C07D211/46; C07D307/84; C07D333/68; C07D403/12; C07D405/12; C07D409/12; C07D417/12

JP4346978A

Miyuki Ariga (3 outside)

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