Title:
【発明の名称】癌マーカー用生物合成結合蛋白質
Document Type and Number:
Japanese Patent JPH08500962
Kind Code:
A
Abstract:
Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.
Inventors:
Haston, James S.
Houston, EL. EL.
Ring, david, bee
Herman, Opperman
Houston, EL. EL.
Ring, david, bee
Herman, Opperman
Application Number:
JP51419793A
Publication Date:
February 06, 1996
Filing Date:
February 05, 1993
Export Citation:
Assignee:
Creative BioMolecules, Incorporated
Setus Oncology Corporation
Setus Oncology Corporation
International Classes:
C12N15/09; A61K39/395; A61K49/00; A61K51/00; A61K51/08; A61P35/00; C07H21/04; C07K16/22; C07K16/28; C07K16/30; C07K16/32; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12N15/66; C12P21/02; C12P21/08; C12R1/19; (IPC1-7): C12N15/09; A61K49/00; A61K51/00; C07H21/04; C07K16/30; C12N1/21; C12P21/02; C12P21/08
Attorney, Agent or Firm:
Yoshihiro Kodama