【発明の名称】N-(4-ヒドロキシフェニル)レチンアミド-O-グルクロニドのC-グリコシド類似物

Title:

【発明の名称】N-(4-ヒドロキシフェニル)レチンアミド-O-グルクロニドのC-グリコシド類似物

Document Type and Number:

Japanese Patent JPH09509680

Kind Code:

A

Abstract:

The present invention provides breast cancer chemopreventive arylamide analogues of retinoic acid, more particularly C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide and N-glycoside analogue of retinoyl beta -glucuronide that resist both beta -glucuronidase mediated enzymatic hydrolysis as well as acid catalyzed hydrolysis. Specifically, the drugs include 4-(retinamido)phenyl-C-glucuronide; 4-(retinamido)phenyl-C-glucoside; 4-(retinamido)benzyl-C-xyloside; 4-(retinamido)benzyl-C-glucoside; 4-(retinamido)benzyl-C-glucuronide; 4-(retinamido)phenyl-C-xyloside, 1-(B-D-glucopyranosyl)retinamide and 1-(D-glucopyranosyluronosyl)retinamide. The invention also relates to a method for making such drugs.

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Inventors:

Curly, Robert WJ
Robage, Michael Jay

Application Number:

JP51115696A

Publication Date:

September 30, 1997

Filing Date:

September 26, 1995

Export Citation:

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Assignee:

The Ohio State Research Foundation

International Classes:

C07H5/06; A61K31/70; A61K31/7008; A61K31/7024; A61P35/00; C07H13/02; C07H13/04; C07H13/06; (IPC1-7): C07H13/02; A61K31/70; C07H5/06

Attorney, Agent or Firm:

Yuzo Yamazaki (1 person outside)

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