Title:
【発明の名称】標的化のための化合物
Document Type and Number:
Japanese Patent JP2003528156
Kind Code:
A
Abstract:
A compound comprising a target cell specific portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has the same apoptosis-inducing activity as a caspase. Alternatively, the invention provides a compound comprising a mediator portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has the same apoptosis-inducing activity as a caspase. Preferably, the cytotoxic portion is a constitutively active caspase-3, caspase-6 or caspase-7, and the target cell specific portion is and antibody specific for a tumour cell antigen, such an HMFG-1 antibody. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, such as in the treatment of cancer.
Inventors:
Agamemnon Antonio Epenethos
Application Number:
JP2001570297A
Publication Date:
September 24, 2003
Filing Date:
March 28, 2001
Export Citation:
Assignee:
Antisoma Research Limited
International Classes:
A61K38/46; A61K39/395; A61K45/00; A61K47/48; A61P35/00; C07K16/18; C07K16/28; C07K16/30; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N9/64; C12N15/13; C12N15/57; C12P21/02; A61K38/00; (IPC1-7): A61K38/46; A61K39/395; A61K47/48; A61P35/00; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Masatake Shiga (7 outside)