【発明の名称】D-ホモステロイド - EFU HOFUMAN RA ROSHU UNTO CO AG

Title:

【発明の名称】D-ホモステロイド

Document Type and Number:

Japanese Patent JPS5910680

Kind Code:

B2

Abstract:

Anti-inflammatory D-homosteroids of the formula in which the dotted 1,2 bond denotes an optional C-C bond; R<6> denotes hydrogen, fluorine, chlorine or methyl; R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha .

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Inventors:

REO ARIKU
ANDORU FUYURUSUTO
MARUSERU MYUURAA
URURITSUHI KERUBU
KURAUSU KIISURITSUHI
RUDORUFU BIIHYAATO

Application Number:

JP10505477A

Publication Date:

March 10, 1984

Filing Date:

September 02, 1977

Export Citation:

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Assignee:

EFU HOFUMAN RA ROSHU UNTO CO AG

International Classes:

A61K31/12; A61K31/57; A61P29/00; C07J63/00; C12P33/08; (IPC1-7): C07J63/00; A61K31/57; C12P33/08

Attorney, Agent or Firm:

Heiyoshi Odashima

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