Title:
【発明の名称】ヒト5-HT↓1↓f受容体をコードするDNAおよびその使用
Document Type and Number:
Japanese Patent JPH06505879
Kind Code:
A
Abstract:
PCT No. PCT/US93/00149 Sec. 371 Date Aug. 22, 1994 Sec. 102(e) Date Aug. 22, 1994 PCT Filed Jan. 8, 1993 PCT Pub. No. WO93/14201 PCT Pub. Date Jul. 22, 1993This invention provides an isolated nucleic acid molecule encoding a human 5-HT1F receptor, an isolated protein which is a human 5-HT1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1F receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1F receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1F receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT1F receptor, pharmaceutical compounds related to human 5-HT1F receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT1F receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT1F receptor.
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Inventors:
Wayne Sheink, Richard Elle
Blanche, Teresa
Heartig, Paul Earl
Blanche, Teresa
Heartig, Paul Earl
Application Number:
JP51258793A
Publication Date:
July 07, 1994
Filing Date:
January 08, 1993
Export Citation:
Assignee:
Synaptic Pharmaceutical Corporation
International Classes:
A61K31/70; A61K31/7088; A61K39/395; A61K48/00; A61P25/00; A61P43/00; C07K14/00; C07K14/705; C07K16/00; C12N5/10; C12N15/02; C12N15/09; C12N15/12; C12P21/02; A01K67/027; C12P21/08; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/577; G01N33/94; A61K38/00; (IPC1-7): C12N15/12; A01K67/027; A61K31/70; A61K39/395; A61K48/00; C07K13/00; C12N5/10; C12N15/06; C12P21/02; C12P21/08; C12Q1/68; G01N33/53; G01N33/566; G01N33/577
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)