Title:
【発明の名称】2―デオキシ―2,3―ジデヒドロ―N―アセチルノイラミン酸の誘導体及び類似体と抗ウイルス剤としてのそれらの用途
Document Type and Number:
Japanese Patent JP2944750
Kind Code:
B2
Abstract:
Neuraminic acid derivs. of formula (I) and (Ia) and their salts are new. A = O, S or C in (I) and N or C in (Ia). R1 = COOH, P(O)(OH)2, NO2, SOOH, SO3H, tetrazol, CH2CHO, CHO or CH(CHO)2. R2 = H, OR6, F, Cl, Br, CN, NHR6, SR6 or CH2X. X = NHR6, halo or OR6. R6 = H, 1-4C acyl, linear or cyclic 1-6C alkyl (or a halo substd. analogue), allyl or aryl (opt. substd. by halo, OH, NO2, NH2 or COOH. R3, R3' = independently H, CN, NH(R6)2, N3, SR6, =N-OR6, OR6, guanidino, N(OR6)R6, NR6 -NHR6-N(R6)2, NR6-O, pyrimidino or pyrimidinomethyl. R4 = NHR6, SR6, OR6, COOR6, NO2, C(R6)3, CH2COOR6, CH2NO2 or CH2NHR6. R5 = CH2-YR6, CH(YR6)-CH2-YR6 or CH(YR6)CH(YR6)CH2-YR6. Y = O, S, NH or H, provided that (i) when R3 or R3' is OR6 or H, and A is O or S, then (I) cannot have both (a) R2 as H and (b) R4 as NH-acyl. (ii) R6 is a covalent bond when Y is H. In (Ia), when R3 or R3' is OR6 or H, and A is N, then (Ia) cannot have both (a) R2 as H and (b) R4 as NH-acyl, and (ii) R6 is a covalent bond when Y is H. 14 compounds are specifically claimed including sodium 5-acetamido -4-azido-2,3,4,5-tetradeoxy -D-galacto-non-2-enopyransonate.
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Inventors:
FUON ITSUSHUTAIN ROORENSU MAAKU
U UENNYAN
FUAN TO BAN
DANIIRETSUKU BAJIRU
JIN BETEII
KOORUMAN PIITAA MARUKOMU
BAAFUESU JOSEFU NOOZUHAMARII
U UENNYAN
FUAN TO BAN
DANIIRETSUKU BAJIRU
JIN BETEII
KOORUMAN PIITAA MARUKOMU
BAAFUESU JOSEFU NOOZUHAMARII
Application Number:
JP50809191A
Publication Date:
September 06, 1999
Filing Date:
April 24, 1991
Export Citation:
Assignee:
BAIOTA SAIANTEIFUITSUKU MANEEJIMENTO PTY LTD
International Classes:
C07D309/30; A61K31/00; A61K31/196; A61K31/34; A61K31/35; A61K31/351; A61K31/38; A61K31/382; A61K31/41; A61K31/435; A61K31/44; A61K31/505; A61K31/7012; A61P31/00; A61P31/12; A61P31/14; C07C47/225; C07C47/42; C07C225/20; C07C233/52; C07C309/25; C07C317/12; C07C321/22; C07D211/70; C07D211/72; C07D211/74; C07D211/78; C07D211/84; C07D239/26; C07D257/02; C07D257/04; C07D309/20; C07D309/22; C07D309/26; C07D309/28; C07D335/02; C07D401/04; C07D401/14; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D498/04; C07F9/655; C07H7/033; C07D; (IPC1-7): C07D309/30; A61K31/00; A61K31/34; C07D211/70; C07D211/72; C07D211/74; C07D211/78; C07D211/84; C07D309/20; C07D309/22; C07D309/26; C07D309/28; C07D335/02
Other References:
Ｃｈｅｍ．Ｐｈａｒｍ．Ｂｕｌｌ．３６［１２］（１９８８）Ｐ．４８０７−４８１３
Attorney, Agent or Firm:
Kazuo Sato (2 outside)