Title:
【発明の名称】ウトロピン遺伝子の発現
Document Type and Number:
Japanese Patent JP2000504931
Kind Code:
A
Abstract:
Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic muscle phenotype in an animal model, indicating usefulness in treatment of muscular dystrophy. The nucleic acid and encoded polypeptides are also useful in screening for substances to modulate utrophin binding to actin and/or the dystrophin protein complex.
Inventors:
Tinsley, jonason, mark
Davis, Kay, Elizabeth
Davis, Kay, Elizabeth
Application Number:
JP52259197A
Publication Date:
April 25, 2000
Filing Date:
December 19, 1996
Export Citation:
Assignee:
Medical Research Council
International Classes:
A61K31/00; A61K38/00; A61K48/00; A61P21/00; A61P21/04; C07K14/47; C12N15/09; C12N5/10; C12N15/12; (IPC1-7): C12N15/09; A61P21/04; A61K48/00; C07K14/47; C12N5/10
Attorney, Agent or Firm:
Takashi Ishida (4 others)