Title:
【発明の名称】蛍光ジベンザゾール誘導体及びこれに関連する方法
Document Type and Number:
Japanese Patent JP2001510190
Kind Code:
A
Abstract:
Dibenzazole compounds having the general structure: wherein; R1, R2, R3, R4, R5, R6 are independently H or a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety; Y is H or a cleavable moiety; X is a hydrogen, halogen, CF3, or SO3H; V and W are oxygen or sulfur; Z is -C=C-, -C 3BOND C- or an aromatic ring moiety; and n is 0, 1, or 2. When n=0 at least one of R1, R2, R3, R4, and R5 is a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety or X is a halogen, CF3 or SO3H. These compounds are highly fluorescent and can be easily detected using a fluorometer. Derivatives in which the Y group is a substituent other than H contain a fluorescence inhibiting chemical moiety that upon removal restores the fluorescence of the compound. Methods for their synthesis and application are provided.
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Inventors:
Brown Lauren Earl
Shu Chen
Shu Chen
Application Number:
JP2000503073A
Publication Date:
July 31, 2001
Filing Date:
July 21, 1998
Export Citation:
Assignee:
Promega Biosciences Inc.
International Classes:
C07D263/62; C07D277/64; C07D277/66; C07D417/06; C07F9/653; C07F9/6541; C07H15/26; C07H17/00; C07H19/04; C07H19/10; C07H19/20; C07H21/00; C07H21/02; C07H21/04; G01N33/53; G01N33/533; G01N33/58; H04N21/443; (IPC1-7): C07F9/653; C07D263/62; C07D277/64; C07D277/66; C07D417/06; C07F9/6541; C07H17/00; C07H19/10; C07H19/20; C07H21/02; C07H21/04; G01N33/53; G01N33/533
Attorney, Agent or Firm:
Minoru Nakamura (9 outside)