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Title:
【発明の名称】免疫修飾ステロイドとくに16α-ブロモエピアンドロステロンのヘミハイドレート
Document Type and Number:
Japanese Patent JP2002540119
Kind Code:
A
Abstract:
The invention provides compositions comprising formula 1 steroids, e.g., 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make improved pharmaceutical formulations. The invention also provides methods of intermittent dosing of steroid compounds such as analogs of 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one and compositions useful in such dosing regimens. The invention further provides compositions and methods to inhibit pathogen (viral) replication, ameliorate symptoms associated with immune dysregulation and to modulate immune responses in a subject using certain steroids and steroid analogs. The invention also provides methods to make and use these immunomodulatory compositions and formulations.

Inventors:
Arlem, Clarence, Nazaniel
Frink, james, martin
De Carvalho, Luis, Daniel, Dos Anjos
Heggie, William
Plendelgast, Patrick, Tee
Reading, Christopher, Elle
Tohadi Conda, Krupakar, Paul
Vernon, Russell, Nail
Application Number:
JP2000606618A
Publication Date:
November 26, 2002
Filing Date:
March 23, 2000
Export Citation:
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Assignee:
Hollis-Eden Pharmaceuticals, Inc.
International Classes:
A61K31/565; A61K31/5685; A61K31/58; A61P31/04; A61P31/12; A61P31/18; A61P31/20; A61P33/00; A61P35/00; A61P37/00; C07J1/00; C07J3/00; C07J9/00; C07J17/00; C07J53/00; C07J73/00; (IPC1-7): C07J1/00; A61K31/565; A61K31/5685; A61K31/58; A61P31/04; A61P31/12; A61P31/18; A61P31/20; A61P33/00; A61P35/00; A61P37/00; C07J9/00; C07J17/00; C07J53/00; C07J73/00
Domestic Patent References:
JPS6425722A1989-01-27
JPH03275634A1991-12-06
JPS6069096A1985-04-19
Attorney, Agent or Firm:
Akira Asamura (3 outside)