Title:
【発明の名称】核内オーファン受容体
Document Type and Number:
Japanese Patent JP2003535912
Kind Code:
A
Abstract:
The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
Inventors:
Crewer, Stephen, A.
Johns, Stacey, A.
Wilson, Timothy, M.
Johns, Stacey, A.
Wilson, Timothy, M.
Application Number:
JP2002503339A
Publication Date:
December 02, 2003
Filing Date:
June 21, 2001
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K45/00; A61P1/16; C07K14/705; A61K38/00; (IPC1-7): A61K45/00; A61P1/16
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)