Title:
【発明の名称】ペプチド系の細胞接着阻害物質
Document Type and Number:
Japanese Patent JPH08503694
Kind Code:
A
Abstract:
PCT No. PCT/US93/08504 Sec. 371 Date Mar. 7, 1995 Sec. 102(e) Date Mar. 7, 1995 PCT Filed Sep. 8, 1993 PCT Pub. No. WO94/05310 PCT Pub. Date Mar. 17, 1994Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cyclization or conformational restriction in conjunction with specific substitutions have been identified that not only unexpectedly enhance the biological activity of these compounds, but also significantly increase their resistance to enzymatic degradation. Formulae of the active compounds and representative examples of preferred peptides are presented herein.
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Inventors:
George A. Hebner
Falcon, Margaret El
Krusinsky, Marian
Falcon, Margaret El
Krusinsky, Marian
Application Number:
JP50753794A
Publication Date:
April 23, 1996
Filing Date:
September 08, 1993
Export Citation:
Assignee:
Centco Incorporated
International Classes:
A61K38/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P29/00; A61P35/00; A61P43/00; C07K7/06; C07K7/64; C07K14/705; (IPC1-7): C07K7/06; A61K38/00; C07K7/64
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)