Title:
【発明の名称】ホスホリパーゼA2抑制剤
Document Type and Number:
Japanese Patent JPH02500030
Kind Code:
A
Abstract:
There are disclosed compounds of the formula wherein R1 is lower alkyl, lower alkoxycarbonyl lower alkyl, aralkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl; R2 is hydrogen, lower alkyl or biphenylyl lower alkylcarbonyl; or R1 and R2 taken together form a 5- or 6-membered saturated heterocyclic ring; R3 is hydrogen or lower alkyl; R4 is alkyl of 10-20 carbon atoms, cycloalkyl of 10-20 carbon atoms or phenylalkyl of 10-16 carbon atoms; or R3 and R4 taken are decahydroisoquinolin-2-yl, 3,5-dimethylpiperazin-1-yl or 3,3,5-trimethylhexahydroazepin-1-yl; or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivities and various inflammatory conditions.
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Inventors:
McGregor, William H
Jung, joseph wai
Jung, joseph wai
Application Number:
JP50299488A
Publication Date:
January 11, 1990
Filing Date:
March 16, 1988
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
C12N9/99; A61K31/16; A61K31/22; A61K31/403; A61K31/404; A61K31/405; A61K31/42; A61K31/445; A61K31/47; A61K31/472; A61K31/495; A61K31/55; A61P11/00; A61P17/00; A61P27/02; A61P27/14; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07C231/12; C07C237/04; C07C237/06; C07C237/22; C07D207/16; C07D209/20; C07D209/42; C07D211/60; C07D217/04; C07D217/06; C07D223/04; C07D241/04; C07D295/15; C07D295/185; C07D401/06; (IPC1-7): A61K31/16; A61K31/22; A61K31/405; A61K31/42; A61K31/445; A61K31/47; A61K31/495; A61K31/55; C07C231/12; C07C237/04; C07C237/06; C07C237/22; C07D207/16; C07D209/20; C07D211/60; C07D217/04; C07D223/04; C07D241/04; C12N9/99
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)