Title:
【発明の名称】多発性嚢胞腎1型遺伝子及びその使用
Document Type and Number:
Japanese Patent JPH09507751
Kind Code:
A
Abstract:
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterised by widespread development of growths in many tissues and organs. A gene (TSC2) is identified on chromosome 16 which is mutated in TSC and which may behave as a tumour suppressor. Screening of actual or suspected TSC patients for normal or mutated TSC2 can be used for diagnostic purposes. TSC2 protein (tuberin) may be used to treat or prevent unrestrained cell division and/or tumour development in patients with or without TSC.
Inventors:
Harris, Peter Charles
Pelar, belem
Ward, christopher james
Fumes, james
Blainck, Martin Hendrick
Peters, Dorothy Johanna Maria
Roelph Sema, Jerun, Hendrick
Sampson, Julian
Harley, Dilce, Jorainche Johanna
Nellist, Marc, Davit
Iansen, Lambertus Anthony Jacobs
Hesselink, Ayenne Rick Wilhelma
Pelar, belem
Ward, christopher james
Fumes, james
Blainck, Martin Hendrick
Peters, Dorothy Johanna Maria
Roelph Sema, Jerun, Hendrick
Sampson, Julian
Harley, Dilce, Jorainche Johanna
Nellist, Marc, Davit
Iansen, Lambertus Anthony Jacobs
Hesselink, Ayenne Rick Wilhelma
Application Number:
JP51785795A
Publication Date:
August 12, 1997
Filing Date:
December 23, 1994
Export Citation:
Assignee:
Medical Research Council
Rayden University
University of Wales College of Medicine
Erasmus University Rotterdam
Rayden University
University of Wales College of Medicine
Erasmus University Rotterdam
International Classes:
G01N33/566; A61K31/70; A61K38/00; A61K39/395; A61K48/00; A61P13/02; A61P13/12; A61P15/00; A61P35/00; C07H21/02; C07H21/04; C07K14/46; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; C12R1/19; (IPC1-7): C12N15/09; C07K14/47; C07K16/18; C12N1/21; C12N5/10; C12P21/02; C12Q1/68; G01N33/566
Attorney, Agent or Firm:
Takashi Ishida (3 others)