Title:
【発明の名称】多座金属錯体並びにこれらを製造する方法及びこれらの使用
Document Type and Number:
Japanese Patent JPH11507641
Kind Code:
A
Abstract:
The invention relates to multidentate metal complexes having formula (I) wherein M is Fe, In, Ga or Al; the dashed lines represent independently a sigle or a double bond; the hatched lines represent coordination to the metal cation (M); A and B are oxygen, or in the case where Ar is 2-pyridyl or 2-pyrrolyl, a shared pair of electrons on the nitrogen; Ar is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted 2-pyridyl or optionally substituted 2-pyrrolyl, with the proviso that at least one of the substituents comprises a boron atom; X is alternatively (i) (CHR<2>)p[NR<3>(CHR<4>)q]r, wherein p and q are independently 1, 2, 3, 4, 5 or 6; r is 0, 1 or 2; and R<2>, R<3> and R<4> are independently hydrogen, lower alkyl or phenyl, or two adjacent R<2> or R<4> groups represent a double bond or a fused benzene ring where p or q, respectively, is greater than 2; with the proviso that where r is 1 or 2, then there are 1 or two additional sites of coordination to the metal; or (ii) optionally substituted phenyl, wherein the phenyl, when substituted, has lower alkyl substituents, optionally with: proviso (A), wherein at least one of the substituents of Ar comprises boron, or with proviso (B), wherein at least one of substituents of Ar comprises a linkage to a pharmaceutically active substituent.
Inventors:
Punica-Warms, David Earl
Sharma, Vijay
Sharma, Vijay
Application Number:
JP50218897A
Publication Date:
July 06, 1999
Filing Date:
June 07, 1996
Export Citation:
Assignee:
WASHINGTON UNIVERSITY
International Classes:
A61K41/00; A61K31/28; A61K31/285; A61K31/555; A61K31/70; A61K38/00; A61K45/00; A61P33/02; A61P35/00; A61P43/00; C07D273/00; C07F5/00; C07F5/06; C07F15/02; (IPC1-7): C07F5/00; A61K31/28; A61K31/285; A61K31/555; A61K31/70; A61K38/00; A61K41/00; A61K45/00; C07F5/06; C07F15/02
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)