Title:
【発明の名称】プロテインキナーゼ活性を有する置換三環式ピラゾール誘導体
Document Type and Number:
Japanese Patent JP2002512962
Kind Code:
A
Abstract:
Chemical compounds that are derivatives of 2H[1]-benzothiepino[5,4-c]pyrazole, 2H[1]-benzoxepino[5,4-c]pyrazole, 1-benzothiopyrano[4,3-c]pyrazole, 1-benzopyrano[4,3-c]pyrazole, 4,5-dihydro-2h-furano[2,3-g]indazole and 4,5-dihydro-2h-thieno[2,3-g]indazole derivatives 2H[1]-benzothiepino[5,4-c]pyrazole, [1]-benzothiopyrano[4,3-c]pyrazole, 4,5-dihydro-2H-furano[2,3-g]indazole and 4,5-dihydro-2H-thieno[2,3-g]indazole derivatives are inhibitors of protein kinase activity. Several of the protein kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic and/or edematous processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis, edema or endothelial cell hyperproliferation or hyperpermeability is a factor. Like cancer, artritis, atherosclerosis, psoriasis, hemangioma, myocardial angiogenesis, coronary and cerebral collaterals, ischemic limb angiogenesis, corneal disease, rubeosis, neovascular glaucoma, macular degeneration, wound healing, peptic ulcer Helicobacter related diseases, fractures, diabetic retinopathy, and cat scratch fever.
Inventors:
Arnold lee
Rafferty, Paul
Hockley, Michael
Turner, Allison
Rafferty, Paul
Hockley, Michael
Turner, Allison
Application Number:
JP2000545533A
Publication Date:
May 08, 2002
Filing Date:
April 28, 1999
Export Citation:
Assignee:
BASF Akchen Gezel Shaft
International Classes:
A61K31/4162; A61K31/4439; A61K31/55; A61P1/04; A61P9/00; A61P9/10; A61P17/02; A61P19/02; A61P19/08; A61P27/02; A61P27/06; A61P35/00; A61P43/00; C07D491/048; C07D491/052; C07D495/04; C07D491/044; (IPC1-7): A61K31/4162; A61K31/4439; A61K31/55; A61P1/04; A61P9/00; A61P9/10; A61P17/02; A61P19/02; A61P19/08; A61P27/02; A61P27/06; A61P35/00; A61P43/00; C07D491/044; C07D491/048; C07D491/052; C07D495/04; C07D231:12; C07D335:06
Attorney, Agent or Firm:
Sato Eto