PURPOSE: A cancer eliminating agent containing a vitamin D having no hydroxyl group at the 1α-positon as an active constitutent.
CONSTITUTION: A cancer eliminating agent containing a vitamin D as an active constituent. The vitamin D has a very powerful differentiation inducing ability against the human myelocytic leukemia HL-60 call in a low concentration. Vitamin D2, vitamin D3, 25-hydroxyvitamin D3, 2α-hydroxyvitamin D3, 2β-hydroxyvitamin D3 and the corresponding 5,6-trans derivatives, tachysterol, etc. may be cited as the vitamin D. 5, 6-cis-Vitamin D, tachysterol, etc. in the vitamin D derivative are prepared by the well-known method. The 5, 6-trans-vitamin D is obtained by reacting the corresponding 5, 6-cis-vitamin D with iodine in an inert solvent. The aimed substance is formulated into a desired form by the conventional method and administered. The dose thereof is 20pgW10μg/ml, and administered as a soft capsule, etc.
MIZUNO KOUJI
KAIHOU SHINICHI
ONODA FUSAYO
OCHI KIYOSHIGE
MATSUNAGA ISAO
