【発明の名称】αVインテグリン受容体拮抗薬としてのジベンゾ-アゼピン誘導体

Title:

【発明の名称】αVインテグリン受容体拮抗薬としてのジベンゾ-アゼピン誘導体

Document Type and Number:

Japanese Patent JP2002537260

Kind Code:

A

Abstract:

The present invention relates to dibenzo-azepine derivatives and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaVbeta3, alphaVbeta5, and/or alphaVbeta6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.

More Like This:

WO/2010/146881	SUBSTITUTED ISOQUINOLINE DERIVATIVE
WO/2009/055749	2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN
WO/2005/030762	BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF

Inventors:

Pattern, Michael A.
Rundle Sea, Newton

Application Number:

JP2000599395A

Publication Date:

November 05, 2002

Filing Date:

February 14, 2000

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Merck End-Campany Inc.

International Classes:

C07D413/12; A61K31/553; A61K45/00; A61P9/00; A61P9/10; A61P19/08; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P35/04; A61P43/00; C07D267/20; (IPC1-7): C07D413/12; A61K31/553; A61K45/00; A61P9/00; A61P9/10; A61P19/08; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P35/04; A61P43/00

Attorney, Agent or Firm:

Yoshio Kawaguchi (5 outside)

Previous Patent: 間歇性跛行治療薬

Next Patent: 高い薬用量でのジエノゲストの使用