Title:
【発明の名称】ホトアフィニティーラベル化法を用いたアルツハイマー病およびその他疾患の検出法
Document Type and Number:
Japanese Patent JP3228421
Kind Code:
B2
Abstract:
The present invention relates to a novel method for the diagnosis of Alzheimer's disease using cerebrospinal fluid. More particularly, this method consists in contacting a sample of cerebrospinal fluid which contains a glutamine synthetase, having an apparent MT of about 42 000 daltons, with a labeled antibody specific for said glutamine synthetase under conditions that allow the formation of glutamine synthetase-antibody complex formation ; detecting the presence of said glutamine synthetase-antibody complexes ; and correlating the presence of said complexes with the presence of Alzheimer's disease.
Inventors:
Halley, Boyd Yi.
Application Number:
JP51174693A
Publication Date:
November 12, 2001
Filing Date:
December 23, 1992
Export Citation:
Assignee:
The University of Kentucky Research Foundation
International Classes:
G01N33/50; A61K39/395; G01N33/53; G01N33/573; G01N33/574; G01N33/60; G01N33/68; (IPC1-7): G01N33/68; G01N33/50
Other References:
【文献】Annals of Neurology,Vol.26,No.2(1989)p210
【文献】Proc.Natl.Acad.Sci.,Vol.88(1991)p10540
【文献】Proc.Natl.Acad.Sci.,Vol.88(1991)p10540
Attorney, Agent or Firm:
Takashi Koshiba