Title:
【発明の名称】新規ピペラジン誘導体、その製造方法及びそれを含有する組成物
Document Type and Number:
Japanese Patent JP2978967
Kind Code:
B2
Abstract:
PCT No. PCT/KR96/00005 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Jan. 10, 1996 PCT Pub. No. WO90/21648 PCT Pub. Date Jul. 18, 1996The present invention relates to novel compound of the general formula(I) and acid addition salt thereof. (I) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl or optionally substituted C3-C6 membered cycloalkyl containing C3-C8 ; R3, R4, R5, R6 and R7 are independently hydrogen, halogen, hydroxy, nitro, C1-C4 lower ester, C1-C4 lower alkyl, C1-C4 lower alkoxy, aryl, arylalkoxy or unsaturated amine; l is an integer of 0-7; m and n are independently an integer of 0-1; W is carbon or nitrogen; X is oxygen, sulfur, optionally substituted imine; Y is nitrogen or oxygen; and Z is hydrogen, C1-C8 alkoxy, aryloxy, C1-C4 alkylamine, cycloamine containing N1-N5 or oxo group. The present compounds of the above formula (I) has no only strong antimumor activities but lower toxicities, and accordingly are expected as novel antitumor agents.
Inventors:
CHO EUIIHOWAN
CHUNGU SUNNGAN
KIMU JUUNGUUYONGU
RII SUNNHOWAN
KUON HOOSEOKU
KIMU BYUNGUUCHURU
KONGU JAEEMIEONGU
RII JAEEEUNGU
KANGU DONGUUUKU
CHUNGU SUNNGAN
KIMU JUUNGUUYONGU
RII SUNNHOWAN
KUON HOOSEOKU
KIMU BYUNGUUCHURU
KONGU JAEEMIEONGU
RII JAEEEUNGU
KANGU DONGUUUKU
Application Number:
JP52157096A
Publication Date:
November 15, 1999
Filing Date:
January 10, 1996
Export Citation:
Assignee:
SANSHIN SEIYAKU KK
International Classes:
A61K31/00; A61K31/44; A61K31/495; A61K31/496; A61P35/00; C07D213/38; C07D213/40; C07D213/64; C07D213/75; C07D215/22; (IPC1-7): C07D213/75; A61K31/00; A61K31/495; C07D213/64; C07D215/22
Domestic Patent References:
| JP2142770A |
Attorney, Agent or Firm:
Hotaka Tetsuo