Title:
【発明の名称】新規なスルホンアミドフィブリノゲン受容体拮抗薬
Document Type and Number:
Japanese Patent JP2812431
Kind Code:
B2
Abstract:
Sulphonamido-phenylalkanoic acid derivs. of formula (I), and their salts, are new. In (I), R1 = Het1 opt. substd. NR6R7, R6R7NC- (=NR6)- R6R7NC(=NR6)NH-, R6C(=NR7)NR7- or a gp. (a) or (b); Het1 = a 4-8 member heterocyclic ring contg. 1-4 heteroatoms from N, O, S; R6, R7 = H, 0-10C alkyl or cycloalkyl, both opt. substd. Het2 = 1-4C alkanoylamino, 1-6C alkoxycarbonyl, 0-6C alkylamino; 1-10C alkylsulphonylamino, 4-10C aralkylsulphonylamino, 4-10C aralkyl, 1-10 1-10C alkaryl, 1-10C alkylthio 4-10C aralkylthio, 1-10C alkylsulphinyl, 4-10C aralkylsulphinyl, 1-10C alkylsulphonyl, 4-10C aralkylsulphonyl, aminosulphonyl, 1-10C alkylaminosulphonyl, 4-10C aralkylsulphonylamino, oxo, thio, or 1- or 2-ethenyl or 3- propenyl, all opt. substd.; "alkyl" = from alkane, alkene or alkyne; alkoxy = O-alkyl; aralkyl and alkaryl contain alkyl as defined above and aryl defined below; Het2 = a 5 or 6 membered satd. heterocyclic ring contg. 1-4 heteroatoms from N, O, S; aryl = a mono- or poly-cyclic ring system of 5- and 6-membered aromatic rings contg. 0-4 heteroatoms from N, O, S; R2, R3 = H, aryl, or 0-10C alkyl or cycloalkyl both opt. substd.; R4 = aryl, 1-10C alkyl or cycloalkyl, 4-1UC aralkyl, 1-10C alkoxyalkyl, 1-10C alkaryl, 1-10C alkylthioalkyl, 1-10C alkoxythioalkyl, 1-10C alkylamino, 4-10C aralkylamino, 1-10C alkanoylamino, 4-10C aralkanoylamino, 1-10C alkanoyl, 4-10C aralkanoyl, or 1-10C carboxyalkyl opt. substd. R5 = Het1, COR8, or CSR8; R8 = e.g. OH, 1-10C alkyloxy, 1-10C alkaryloxy, etc. X. Y, Z are opt. substits. and = NR6, O, S, SO, CO, CS CH(OH), SO2, CR6=CR7, CC, Het1, (opt. substd. at any atom with R6), aryl, CONR6, NR6CO, NR6SO2, or SO2NR6; m = 0-10; n = 0-10; and p = 0-3.
Inventors:
Melissa S. Egbertson
George Day. Hartman
Wasil Halchenko
William El. Lasswell
Mark E. Duggan
George Day. Hartman
Wasil Halchenko
William El. Lasswell
Mark E. Duggan
Application Number:
JP20186496A
Publication Date:
October 22, 1998
Filing Date:
July 31, 1996
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/185; A61K31/195; A61K31/215; A61K31/255; A61K31/265; A61K31/40; A61K31/4015; A61K31/41; A61K31/415; A61K31/42; A61K31/421; A61K31/435; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/4433; A61K31/445; A61K31/4465; A61K31/451; A61K31/452; A61K31/495; A61K31/496; A61K31/505; A61K31/55; A61K31/66; A61P7/02; A61P43/00; C07C311/02; C07C311/06; C07C311/13; C07C311/19; C07C313/06; C07C313/20; C07C317/26; C07D211/30; C07C317/44; C07C323/59; C07C327/12; C07D207/08; C07D207/09; C07D207/10; C07D207/12; C07D207/26; C07D207/273; C07D209/12; C07D209/30; C07D211/18; C07D211/20; C07D211/22; C07D211/26; C07D211/32; C07D211/46; C07D213/75; C07D223/08; C07D233/02; C07D233/64; C07D237/08; C07D239/04; C07D239/26; C07D241/04; C07D241/12; C07D249/04; C07D249/08; C07D263/46; C07D267/10; C07D401/12; C07D401/14; C07D403/10; C07D403/12; C07D403/14; C07D409/12; C07D413/12; C07D413/14; C07D453/02; C07D453/06; C07D471/08; C07D487/08; C07F9/38; C07F9/40; (IPC1-7): C07C311/06; A61K31/195; A61K31/215; A61K31/40; A61K31/41; A61K31/42; A61K31/44; A61K31/445; A61K31/495; A61K31/505; A61K31/55; C07C311/19; C07D207/08; C07D207/09; C07D207/12; C07D207/273; C07D211/18; C07D211/22; C07D211/46; C07D213/75; C07D223/08; C07D233/64; C07D237/08; C07D239/26; C07D241/12; C07D263/46; C07D267/10; C07D401/12; C07D401/14; C07D403/10; C07D403/12; C07D403/14; C07D409/12; C07D413/12; C07D413/14
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)