Title:
【発明の名称】延長第一シグナル伝達モチーフを有するポリペプチド
Document Type and Number:
Japanese Patent JP2003516127
Kind Code:
A
Abstract:
The invention relates to novel primary signalling motifs, which contain the consensus amino acid sequence of Y-X2-L/I-Xn-Y-X2-L/I, where n is 9 or greater. These novel motifs are extremely efficient at mediating immune cell signal transduction, particularly when incorporated in an intracellular signalling domain of a chimeric receptor. Nucleic acids that encode, and polypeptides that contain, such non-natural stimulatory primary signalling motifs are described, which are suitable for use in medicine.
Inventors:
Finney, Helen, Margaret
Lawson, Alastair, David, Griffiths
Lawson, Alastair, David, Griffiths
Application Number:
JP2001535549A
Publication Date:
May 13, 2003
Filing Date:
November 01, 2000
Export Citation:
Assignee:
Celtec R&D Limited
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P3/10; A61P7/06; A61P11/06; A61P17/00; A61P17/06; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P37/06; C07K14/47; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/62; (IPC1-7): C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P3/10; A61P7/06; A61P11/06; A61P17/00; A61P17/06; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P37/06; C07K14/47; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Akira Asamura (3 outside)
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