【発明の名称】シアノグアニジン誘導体の製造法

Title:

【発明の名称】シアノグアニジン誘導体の製造法

Document Type and Number:

Japanese Patent JPS6056139

Kind Code:

B2

Abstract:

A pharmacologically active cyanoguanidine derivative, generally referred to as cimetidine, is prepared by causing 4-methyl-5-hydroxymethylimidazole or a salt thereof to react with 2-substituted-1-methyl pyridinium salt and then causing the intermediate reaction product to react with N-cyano-N'-methyl-N''-(2-melcaptoethyl)-guanidine. The initial and subsequent reactions are carried out at room temperature under atmospheric pressure, using one and the same reaction vessel. No isolation of the intermediate reaction product resulting from the first reaction is required preparatory to the subsequent reaction. The recovery of the final intended product is carried out without using a column chromatography.

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Inventors:

FUJIMOTO DOTARO
FUKUI RYUICHI
SHIGEARI TOSHIMITSU
FUNATSUKURI GIICHI

Application Number:

JP16602880A

Publication Date:

December 09, 1985

Filing Date:

November 26, 1980

Export Citation:

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Assignee:

FUJIMOTO SEIYAKU KK

International Classes:

C07D213/61; C07D233/54; C07D233/64; (IPC1-7): C07D233/64

Attorney, Agent or Firm:

Miyazaki Shinhachiro

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