Title:
ALPHA-POLYOLEFINC CARBOXYLIC ACIDS AND DERIVATIVES FOR PSORIASIS
Document Type and Number:
Japanese Patent JPS5920266
Kind Code:
A
Abstract:
Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH2,NHR2 or NR2R2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis.
Inventors:
BAANAADO RABU
WANNKITSUTO CHIYAN
HOWAADO JIYOONZU
WANNKITSUTO CHIYAN
HOWAADO JIYOONZU
Application Number:
JP11533283A
Publication Date:
February 01, 1984
Filing Date:
June 28, 1983
Export Citation:
Assignee:
USV PHARMA CORP
International Classes:
A61K31/16; A61K31/165; A61K31/19; A61K31/22; A61K31/20; A61K31/215; A61K31/23; A61P17/00; C07C57/26; C07C67/00; C07C69/608; C07C401/00; C07C403/00; C07C403/20; (IPC1-7): A61K31/20; A61K31/23; C07C175/00
Domestic Patent References:
| JPS4931645A | 1974-03-22 |
Foreign References:
| US3934028A | 1976-01-20 |
Attorney, Agent or Firm:
Ryoji Kawase