To provide a tractor-trailer truck operation management system that is suitable for interregional distribution utilizing a ferry for transport of products by a reefer tractor-trailer truck and is capable of performing quality control of the products along with operation planning .

An operation management server 7 in which operation management data of the tractor-trailer truck 3 equipped with a refrigerator for each vehicle number and refrigerator management data of the refrigerator are entered, an operation management terminal 14 where operation management data of the tractor-trailer truck 3b are entered, and a vehicle mounted device 5 that outputs position information of the truck 3b, information of a temperature inside a refrigerator, or data for managing the refrigerator, information of operation of a refrigerating machine, and information of opening and closing of the door of the refrigerator are connected through a communication means 20. The respective data are collected by a server 7 by associating with the vehicle number of the truck 3b, and the operation management can be executed by grasping the operation of the truck 3b from a place of shipment to a place of delivery for each vehicle number.