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Title:
トランス-2-デセン酸誘導体及びこれを含有する医薬
Document Type and Number:
Japanese Patent JP5044059
Kind Code:
B2
Abstract:
An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury or an alleviating agent for side effect induced by administration of anti-cancer agents.

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Inventors:
Iinuma Sowa
Furukawa Shoei
Mitsuru Uchiki
Tomonori Matsumoto
Hachiro Sugimoto
Application Number:
JP2012513796A
Publication Date:
October 10, 2012
Filing Date:
November 01, 2011
Export Citation:
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Assignee:
Nagoya Institute of Industrial Science
Nippon Organ Pharmaceutical Co., Ltd.
International Classes:
C07C219/06; A61K31/16; A61K31/165; A61K31/167; A61K31/215; A61K31/221; A61K31/265; A61K31/40; A61P3/10; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P39/02; C07C69/533; C07C233/09; C07C233/38; C07C323/12; C07C327/22; C07D295/12
Domestic Patent References:
JP2007510634A2007-04-26
JP2007510634A2007-04-26
Foreign References:
US20090124701A12009-05-14
US20090124701A12009-05-14
Other References:
JPN6012024365; Ｓｙｎｌｅｔｔ ｎｏ．８, 2001, ｐ．１２７２-４
Attorney, Agent or Firm:
Ikuo Fujii



 
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