Title:
trans4-(3,4-ジクロロフェニル)-1,2,3,4-テトラヒドロ-1-ナフタレンアミン及びそのホルムアミドを用いる疼痛性障害の治療
Document Type and Number:
Japanese Patent JP2009538925
Kind Code:
A
Abstract:
Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- 1 -napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful in treatment of pain disorders.
Inventors:
Tarantino, paul
Campbell, Una
Bush, rally
Campbell, Una
Bush, rally
Application Number:
JP2009513347A
Publication Date:
November 12, 2009
Filing Date:
March 30, 2007
Export Citation:
Assignee:
Sepracor, ink.
International Classes:
A61K31/135; A61K9/20; A61K9/48; A61K31/165; A61P21/00; A61P25/00; A61P25/04; C07C211/42
Attorney, Agent or Firm:
Kenichi Morita
Kenjiro Yamaguchi
Kenjiro Yamaguchi