Title:
TREATMENT WITH ANGIOGENIN AND ITS MUTANT
Document Type and Number:
Japanese Patent JP2014185178
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To solve a problem wherein the significance of low level of circulatory VEGF because mutations of VEGF HRE or coding sequence are not confirmed in a patient of ALS.SOLUTION: This invention relates to use of angiogenin or a fragment or variant thereof for treating diseases or conditions characterized by neuronal injury or death, or axonal degeneration, especially neurodegenerative disease such as Amyotrophic Lateral Sclerosis (ALS). This invention also describes a plurality of mutations in the human angiogenin gene which are associated with a neurodegenerative disease phenotype, and particularly an ALS phenotype. This invention further describes a method for assessing whether or not an individual is afflicted with, or genetically predisposed to develop, a disease or condition characterized by neuronal injury or death or axonal degeneration.
Inventors:
MATT GREENWAY
HARDIMAN ORLA
HARDIMAN ORLA
Application Number:
JP2014132976A
Publication Date:
October 02, 2014
Filing Date:
June 27, 2014
Export Citation:
Assignee:
ROYAL COLLEGE OF SURGEONS IE
International Classes:
A61K38/00; A61K48/00; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; C07K14/515; C12N15/09
Domestic Patent References:
| JPH0532557A | 1993-02-09 | |||
| JPH0616564A | 1994-01-25 | |||
| JPH06211660A | 1994-08-02 | |||
| JPH06157338A | 1994-06-03 | |||
| JPH0525056A | 1993-02-02 | |||
| JP2000506894A | 2000-06-06 | |||
| JP2002504370A | 2002-02-12 | |||
| JP2002507191A | 2002-03-05 | |||
| JPWO0121214A1 |
Attorney, Agent or Firm:
Patent business corporation A valley and Abe patent firm