NEW MATERIAL: A compd. represented by formula I [wherein V is O, S, NR (wherein R is H or a 1-4C or 1-4C alkyl or -CH2-, R1 and R2 are each H, OH, a 1-6C alkyl, alkoxy, halogen or 1-4 substituents at a benzo region of CF3CN, R3 and R4 are H or a 1-6C alkyl or combined with N to form a 5- or 6-membered heterocycle] and a salt thereof.
EXAMPLE: 3-Chloro-6,7-dihydro-N-methyl-5H-dibenzo[b,g]-oxogen-6amine hydrochloride.
USE: A medicine having strong anti-dopamine and anti-5HT2 activity and useful for use as antipsychotic compd. having no side effect of an extrapyramidal tract.
PROCESS: For example, a ketone represented by formula II and amine represented by formula III are reduced and aminated in the presence of a reducing agent such as metal hydride like formic acid or LiAlH4 to obtain the compd. represented by the formula I.
| WO/2002/060423 | SUBSTITUTED CARBOSTYRIL DERIVATIVES AS 5-HT¿1A? RECEPTOR SUBTYPE AGONISTS |
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| WO/2019/194850 | AIR POLLUTION CLINICAL SEQUALAE TREATED BY AN HERBAL SUPPLEMENT |
JIEEMUSU KEENZU
