TRICYCLIC HETEROCYCLIC COMPOUNDS, METHOD FOR PRODUCING THE SAME AND AGENT USED THEREFOR

Japanese Patent JP3358069

B2

PURPOSE: To provide a new compound exhibiting a lipoperoxide production- inhibiting activity and a lipoxygenase-inhibiting activity and useful as an agent for preventing.treating cancer, arterial sclerosis, hepatic diseases, cerebrovascular diseases, inflammation, etc.
CONSTITUTION: A compound of formula I [A is (substituted)1-3C alkylene, bond; The B ring is (substituted)aromatic ring; one of W1, W2 is N, and the other is S; R1 is H, (substututed)hydrocarbon, (substituted)heterocylic group, (substituted)alkoxycarbonyl; R2 is H, (substituted)hydrocarbon group, (substituted) heterocyclic ring. (substituted)carboxylic acid, etc.,]. For example, 3- acetylamino-1-phenyl-2,3,4,5-terahydro-1H-[1]benzazepine-2-one. The compound of formula I is obtained e.g. by reacting a compound of formula II (X is releasable group) with a compound of formula III.

WO/2015/054612	TREATING ORGAN-SPECIFIC T CELL MEDIATED AUTOIMMUNE DISEASES
JPH09143071	CONDENSED IMIDAZOLE DERIVATIVE, PRODUCTION AND USE THEREOF
JPS5942361	NOVEL THIOETHER DERIVATIVE

Tetsuya Aono
Osamu Uchikawa

JP33140892A

December 16, 2002

December 11, 1992

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Takeda GmbH

A61K31/425; A61K31/4745; A61K31/55; A61P3/06; A61P39/06; A61P43/00; C07D215/38; C07D223/16; C07D513/04; (IPC1-7): C07D513/04; A61K31/4745; A61K31/55; A61P39/06; C07D215/38; C07D223/16

Ｊ．Ｏｒｇ．Ｃｈｅｍ．，米国，１９７６年，Ｖｏｌ．４１，Ｎｏ．１，ｐ．１２９−１３３
Ｋｈｉｍ．Ｇｅｔｅｒｏｔｓｉｋｌ．Ｓｏｅｄｉｎ．，ロシア，１９８８年，Ｎｏ．９，ｐ．１２７８−１２８３
Ｚｈ．Ｏｒｇ．Ｋｈｉｍ．ロシア，１９８７年，Ｖｏｌ．２３，Ｎｏ．３，ｐ．６３１−６３７
Ｚｈ．Ｖｓｅｓ．Ｋｈｉｍ．Ｏ−ｖａ，．ロシア，１９７８年，Ｖｏｌ．２３，Ｎｏ．６，ｐ．７１１−７１２
Ｚｈ．Ｖｓｅｓ．Ｋｈｉｍ．Ｏ−ｖａ．ｉｍ．Ｄ．Ｉ．Ｍｅｎｄｅｌｅｅｖａ，ロシア，１９８６年，Ｖｏｌ．３１，Ｎｏ．２，ｐ．２２９−２３１
Ｚｈ．Ｖｓｅｓ．Ｋｈｉｍ．Ｏｂｓｈｃｈｅｓｔ．，ロシア，１９７３年，Ｖｏｌ．１８，Ｎｏ．６，ｐ．７１４−７１５
井本稔 他編，大有機化学１５ 複素環式化合物ＩＩ，日本，朝倉書店，１９６５年１０月３０日，第６版，ｐ．８１−８３

Sekiguchi Yo (2 people outside)

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