Title:
トリゴネリンベースの化合物
Document Type and Number:
Japanese Patent JP2019508505
Kind Code:
A
Abstract:
本発明は、改善された溶解度及び変更された薬物動態特性を有する新規な化合物を提供する。本発明の化合物は、式（Ｉ）で表すことができる。
Inventors:
Dugar, sandeep
Mahajan, Dinesh
Sen, Som Dutter
Mahajan, Dinesh
Sen, Som Dutter
Application Number:
JP2019500052A
Publication Date:
March 28, 2019
Filing Date:
March 14, 2017
Export Citation:
Assignee:
SPHAERA PHARMA PVT. LTD.
International Classes:
C07D213/80; A61K31/4425; A61K31/4427; A61K31/444; A61K31/4709; A61K31/4985; A61K31/506; A61K47/54; A61P1/04; A61P1/06; A61P1/08; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/08; A61P9/12; A61P11/06; A61P11/14; A61P13/06; A61P15/10; A61P17/04; A61P19/02; A61P21/02; A61P23/00; A61P25/00; A61P25/04; A61P25/06; A61P25/20; A61P25/24; A61P31/04; A61P31/12; A61P35/00; C07D401/14; C07D405/12; C07D405/14; C07D471/14
Domestic Patent References:
| JP2015535849A | 2015-12-17 | |||
| JPH06501007A | 1994-01-27 | |||
| JP2012524113A | 2012-10-11 |
Foreign References:
| US5411984A | 1995-05-02 | |||
| EP1336602A1 | 2003-08-20 | |||
| US20110046599A1 | 2011-02-24 | |||
| WO2015123595A1 | 2015-08-20 |
Other References:
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K.C.NICOLAOU, J.RENAUD, P.G.NANTERMET, E.A.COULADOUROS, R.K.GUY, AND W.WRASIDLO: "Chemical Synthesis and Biological Evaluation of C-2 Taxoids", J.AM.CHEM.SOC., vol. 117, JPN6021008355, 1995, pages 2409 - 2420, XP002000809, ISSN: 0004823242, DOI: 10.1021/ja00114a005
TORRENCE, PAUL F.; KINJO, JUNEI; KHAMNEI, SHAHRZAD; GREIG, NIGEL H.: "Synthesis and pharmacokinetics of a dihydropyridine chemical delivery system for the antiimmunodefic", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36(5), JPN6021008358, 1993, pages 529 - 37, ISSN: 0004823243
MIYAKE, A.; BODOR, N.: "Improved delivery through biological membranes. XXXV: Synthesis of novel bioreversible redox derivat", PHARMACEUTICAL SCIENCE COMMUNICATIONS, vol. 4(4), JPN7021000768, 1994, pages 231 - 7, ISSN: 0004823244
CHIKHALE, PRASHANT J.; VENKATRAGHAVAN, VASU; BODOR, NICHOLAS S.: "Improved delivery through biological membranes LX: intradermal targeting of acyclovir using redox-ba", DRUG DELIVERY, vol. 3(1), JPN7021000769, 1996, pages 17 - 26, ISSN: 0004823245
H,H,M.ABDU-ALLAH, A.M.ABDEL-MOTY AND A.A.EL-SHORBAGI: "SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANA", BULL.PHARM,SCI., ASSIUT UNIVERSITY, vol. 28, JPN7021000770, 2005, pages 237 - 253, XP055424710, ISSN: 0004823246
LARSEN, C. S. ET AL., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, vol. Charpter 14, JPN6014038866, 2002, pages 460 - 514, ISSN: 0004823247
K.C.NICOLAOU, J.RENAUD, P.G.NANTERMET, E.A.COULADOUROS, R.K.GUY, AND W.WRASIDLO: "Chemical Synthesis and Biological Evaluation of C-2 Taxoids", J.AM.CHEM.SOC., vol. 117, JPN6021008355, 1995, pages 2409 - 2420, XP002000809, ISSN: 0004823242, DOI: 10.1021/ja00114a005
TORRENCE, PAUL F.; KINJO, JUNEI; KHAMNEI, SHAHRZAD; GREIG, NIGEL H.: "Synthesis and pharmacokinetics of a dihydropyridine chemical delivery system for the antiimmunodefic", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36(5), JPN6021008358, 1993, pages 529 - 37, ISSN: 0004823243
MIYAKE, A.; BODOR, N.: "Improved delivery through biological membranes. XXXV: Synthesis of novel bioreversible redox derivat", PHARMACEUTICAL SCIENCE COMMUNICATIONS, vol. 4(4), JPN7021000768, 1994, pages 231 - 7, ISSN: 0004823244
CHIKHALE, PRASHANT J.; VENKATRAGHAVAN, VASU; BODOR, NICHOLAS S.: "Improved delivery through biological membranes LX: intradermal targeting of acyclovir using redox-ba", DRUG DELIVERY, vol. 3(1), JPN7021000769, 1996, pages 17 - 26, ISSN: 0004823245
H,H,M.ABDU-ALLAH, A.M.ABDEL-MOTY AND A.A.EL-SHORBAGI: "SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANA", BULL.PHARM,SCI., ASSIUT UNIVERSITY, vol. 28, JPN7021000770, 2005, pages 237 - 253, XP055424710, ISSN: 0004823246
LARSEN, C. S. ET AL., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, vol. Charpter 14, JPN6014038866, 2002, pages 460 - 514, ISSN: 0004823247
Attorney, Agent or Firm:
Tomohiro Sakamoto