Title:
TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS
Document Type and Number:
Japanese Patent JP2023011941
Kind Code:
A
Abstract:
To provide human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein.SOLUTION: Provided is a recombinant HIV envelope protein, comprising two or more of the following amino acid residues: (i) Phe, Leu, Met, or Trp, preferably Phe, at position 651; (ii) Phe, Ile, Met, or Trp, preferably Ile, at position 655; (iii) Asn or Gin, preferably Asn, at position 535; (iv) Val, Ile or Ala, preferably Val, at position 589; (v) Phe or Trp, preferably Phe, at position 573; (vi) Ile at position 204; and/or (vii) Phe, Met, or Ile, preferably Phe, at position 647, the numbering of the positions being according to the numbering in gp160 of HIV-1 isolate HXB2.SELECTED DRAWING: None
Inventors:
Rutten, Lucy
Touluan, Daphne
Strocappe, Nika, Mindy
Langedijk, John, Petras, Maria
Touluan, Daphne
Strocappe, Nika, Mindy
Langedijk, John, Petras, Maria
Application Number:
JP2022181566A
Publication Date:
January 24, 2023
Filing Date:
November 14, 2022
Export Citation:
Assignee:
JANSSEN VACCINES & PREVENTION B.V.
International Classes:
C12N15/49; A61K35/761; A61K39/21; A61K48/00; A61P31/18; A61P37/04; C07K14/155; C07K17/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/861; C12P21/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Iwata Koichi
Eiji Katayama
Junko Kobayashi
Norio Omori
Iwata Koichi
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