Title:
UCN-1028D DERIVATIVE
Document Type and Number:
Japanese Patent JPH02289531
Kind Code:
A
Abstract:
NEW MATERIAL:An UCN-1028D derivative of formula I [R is H, formula II [Y is C=O, C(=O)O, C(=O)NH, SO2; n is 0-4; Z is O, NH or single bond; R1 is aryl or heterocyclic ring; X1 is H, OR2 (R2 is H, alkyl, etc.), etc.], -Y-R6 (R6 is alkyl, cyclic alkyl, etc.)].
USE: An anti-tumor agent having a protein kinase activity and an anti-tumor activity.
PREPARATION: For example, UCN-1028A or UCN-1028C is hydrolyzed with an alkali to provide the UCN-1028D.
Inventors:
KISHI MITSUO
SAITO HIROMITSU
SANO HIROSHI
TAKAHASHI ISAMI
TAMAOKI TATSUYA
SAITO HIROMITSU
SANO HIROSHI
TAKAHASHI ISAMI
TAMAOKI TATSUYA
Application Number:
JP8120089A
Publication Date:
November 29, 1990
Filing Date:
March 31, 1989
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K31/12; A61K31/255; A61K31/265; A61K31/44; A61K31/4409; A61K31/495; A61P35/00; A61P43/00; C07C46/00; C07C49/755; C07C50/36; C07C69/00; C07C69/025; C07C69/734; C07C69/96; C07C205/57; C07C229/08; C07C229/36; C07C255/57; C07C271/12; C07C271/28; C07C309/66; C07C309/73; C07C327/22; C07C327/32; C07D207/16; C07D207/327; C07D213/79; C07D241/24; C07D307/68; C07D521/00; (IPC1-7): A61K31/12; A61K31/255; A61K31/265; A61K31/44; A61K31/495; C07C46/00; C07C50/36; C07C69/025; C07C69/734; C07C69/96; C07C229/08; C07C229/36; C07C255/57; C07C309/66; C07C309/73; C07C327/22; C07D207/327; C07D213/79; C07D241/24; C07D307/68; C07D521/00