Title:
PHYSIOLOGICALLY ACTIVE SUBSTANCE TAN-1085, AGLYCONE, PREPARATION AND USE THEREOF
Document Type and Number:
Japanese Patent JPH02289532
Kind Code:
A
Abstract:
NEW MATERIAL:TAN-1085 of the formula (R is rhodinosyl or H) or an aglycone thereof.
USE: An arterialization inhibitor. An aromatase inhibitor. A strong small molecule. Useful for breast cancers, endometritis, corpus uteri cancers, ovarium cancers, polycystic ovary diseases, prostatic hypertrophy, birth control, etc.
PREPARATION: A microorganism (e.g. an actinomycetes S-11106 belonging to the genus Streptomyces) belonging to the genus Streptomyces and having an ability to produce the physiologically active substance TAN-1085 is cultured in a medium to accumulate the produced compound of the formula, followed by collecting the compound to provide the physiologically active substance TAN-1085.
Inventors:
KANAMARU TSUNEO
NOZAKI YUKIMASA
MUROI MASAYUKI
NOZAKI YUKIMASA
MUROI MASAYUKI
Application Number:
JP926390A
Publication Date:
November 29, 1990
Filing Date:
January 17, 1990
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/045; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61P9/00; A61P27/02; C07C46/00; C07C50/36; C07H15/24; (IPC1-7): A61K31/045; A61K31/70; C07C46/00; C07C50/36; C07H15/24
Attorney, Agent or Firm:
Tadao Asahina (2 outside)