Title:
勃起障害の治療における他の薬物の効果を増強するために用いる医薬の生産における2,5-ジヒドロキシベンゼンスルホン酸誘導体の使用
Document Type and Number:
Japanese Patent JP2005501031
Kind Code:
A
Abstract:
Use of 2,5-dihydroxy-benzenesulfonic (or 1,4-disulfonic) acid calcium or diethylammonium salts (I) for potentiating the effect of agents (II) for stimulating penile erection in humans. Use of 2,5-dihydroxy-benzenesulfonic acid derivatives of formula (I) in the production of a medicament for potentiating the effect of agents (II) for stimulating penile erection in humans, where (II) are selected from phosphodiesterase V inhibitors, apomorphine, nitrogen monoxide donors, agents for increasing cyclic guanosine monophosphate (cGMP) levels in penile tissue and other agents for this purpose. [Image] R : H or DSO 3 ->; A : Ca 2> +> or N +>H 2Et 2; and n, m : 1 or 2. ACTIVITY : Vasotropic. In isolated human corpus cavernosum, calcium dobesilate (Ia) at a concentration of 10 mu M significantly increased the relaxation of resistant arteries produced by specific concentrations of the phosphodiesterase inhibitor sildenafil (IIa). The relaxation was ca. 25% in presence of 10 nM (IIa) alone and ca. 65% in presence of 10 nM (IIa) and 10 mu M (Ia). MECHANISM OF ACTION : Promotion of relaxation of resistant arteries in the penis.
Inventors:
Esteve-Sorrel, Jose
Saens De Tehada-Golman, Inigo
Saens De Tehada-Golman, Inigo
Application Number:
JP2003510106A
Publication Date:
January 13, 2005
Filing Date:
July 01, 2002
Export Citation:
Assignee:
Laboratorios del D. Esteve S.A.
International Classes:
A61K31/185; A61K45/06; A61P15/10; A61P43/00; (IPC1-7): A61K31/185; A61P15/10; A61P43/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama